Laurence Booth Selected Research

Drug Combinations

1/2021	The development of multi-kinase inhibitors as pancreatic cancer therapeutics.
1/2020	Metabolism of Histone Deacetylase Proteins Opsonizes Tumor Cells to Checkpoint Inhibitory Immunotherapies.
1/2019	Prior exposure of pancreatic tumors to [sorafenib + vorinostat] enhances the efficacy of an anti-PD-1 antibody.
1/2018	[Neratinib + Valproate] exposure permanently reduces ERBB1 and RAS expression in 4T1 mammary tumors and enhances M1 macrophage infiltration.
1/2018	Unconventional Approaches to Modulating the Immunogenicity of Tumor Cells.
1/2018	The CHK1 inhibitor SRA737 synergizes with PARP1 inhibitors to kill carcinoma cells.
4/2016	Ruxolitinib synergizes with DMF to kill via BIM+BAD-induced mitochondrial dysfunction and via reduced SOD2/TRX expression and ROS.
1/2016	Rationally Repurposing Ruxolitinib (Jakafi (®)) as a Solid Tumor Therapeutic.
9/2015	Nexavar/Stivarga and viagra interact to kill tumor cells.
1/2015	Celecoxib enhances [sorafenib + sildenafil] lethality in cancer cells and reverts platinum chemotherapy resistance.

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Laurence Booth Research Topics

Disease

60	Neoplasms (Cancer) 01/2022 - 02/2012
8	Breast Neoplasms (Breast Cancer) 01/2022 - 12/2012
7	Ovarian Neoplasms (Ovarian Cancer) 01/2019 - 01/2015
6	Colonic Neoplasms (Colon Cancer) 01/2022 - 09/2015
6	Carcinoma (Carcinomatosis) 01/2019 - 05/2013
5	Melanoma (Melanoma, Malignant) 01/2022 - 03/2017
5	Brain Neoplasms (Brain Tumor) 01/2016 - 12/2012
4	Colorectal Neoplasms (Colorectal Cancer) 01/2022 - 12/2013
4	Sarcoma (Soft Tissue Sarcoma) 01/2021 - 01/2019
4	Pancreatic Neoplasms (Pancreatic Cancer) 01/2021 - 01/2019
4	Multiple Sclerosis 01/2020 - 01/2014
4	Lung Neoplasms (Lung Cancer) 01/2019 - 04/2016
3	Glioma (Gliomas) 01/2020 - 10/2014
3	Mitochondrial Diseases (Mitochondrial Disease) 01/2020 - 04/2016
2	Hepatocellular Carcinoma (Hepatoma) 01/2020 - 01/2019
2	Ataxia Telangiectasia (Louis Bar Syndrome) 01/2019 - 03/2014
2	Mumps 10/2016 - 10/2015
2	Primary Myelofibrosis (Myelosclerosis) 04/2016 - 01/2016
2	Virus Diseases (Viral Diseases) 10/2015 - 07/2015
2	Hepatitis A (Hepatitis, Infectious) 10/2015 - 07/2015
2	Glioblastoma (Glioblastoma Multiforme) 10/2014 - 01/2014
2	B-Cell Lymphoma (Lymphoma, B Cell) 03/2014 - 10/2013
1	Actinic Keratosis 02/2022
1	Renal Cell Carcinoma (Grawitz Tumor) 01/2022
1	Kidney Neoplasms (Kidney Cancer) 01/2022
1	Alzheimer Disease (Alzheimer's Disease) 12/2021
1	Lymphoma (Lymphomas) 11/2020
1	Liver Neoplasms (Liver Cancer) 01/2020
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2019
1	Uveal melanoma 01/2019

Drug/Important Bio-Agent (IBA)

17	neratinibIBA 01/2022 - 10/2017
16	Pharmaceutical PreparationsIBA 01/2022 - 02/2012
15	Phosphotransferases (Kinase)IBA 01/2022 - 10/2013
14	Histone Deacetylase InhibitorsIBA 01/2022 - 10/2013
14	Drug CombinationsIBA 01/2021 - 12/2012
13	Proteins (Proteins, Gene)FDA Link 12/2021 - 10/2013
13	Sorafenib (BAY 43-9006)FDA Link 01/2021 - 10/2013
12	Sildenafil Citrate (Viagra)FDA Link 01/2019 - 01/2015
9	Beclin-1IBA 11/2020 - 10/2013
8	Histone Deacetylases (Histone Deacetylase)IBA 01/2022 - 03/2017
8	Valproic Acid (Depakote)FDA LinkGeneric 01/2020 - 10/2013
7	regorafenibIBA 01/2021 - 10/2013
7	Pemetrexed (MTA)FDA Link 01/2019 - 01/2015
7	Phosphodiesterase 5 InhibitorsIBA 01/2019 - 03/2014
6	AfatinibIBA 01/2019 - 04/2016
5	Death Domain ReceptorsIBA 01/2022 - 10/2014
5	pazopanib FDA Link 01/2019 - 10/2015
5	AntibodiesIBA 01/2019 - 09/2017
5	Type 5 Cyclic Nucleotide PhosphodiesterasesIBA 11/2017 - 03/2014
5	Endoplasmic Reticulum Chaperone BiPIBA 10/2016 - 02/2012
5	Lapatinib (GW572016)FDA Link 06/2016 - 12/2012
5	OSU 03012IBA 08/2015 - 02/2012
4	ErbB Receptors (EGF Receptor)IBA 01/2022 - 12/2012
4	entinostat (MS 275)IBA 01/2021 - 01/2019
4	Dimethyl FumarateIBA 01/2020 - 01/2014
4	Fingolimod Hydrochloride (FTY720)FDA Link 01/2020 - 01/2014
4	Caspase 9IBA 01/2019 - 10/2013
4	Biomarkers (Surrogate Marker)IBA 01/2019 - 05/2013
3	Fluorouracil (Carac)FDA LinkGeneric 02/2022 - 11/2020
3	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2021 - 03/2014
3	CASP8 and FADD-Like Apoptosis Regulating Protein (FLIP-S)IBA 01/2020 - 03/2016
3	Paclitaxel (Taxol)FDA LinkGeneric 01/2019 - 03/2014
3	niraparibIBA 01/2018 - 01/2018
3	Celecoxib (Celebrex)FDA Link 08/2015 - 01/2015
3	Cisplatin (Platino)FDA LinkGeneric 01/2015 - 03/2014
2	Axitinib (AG 013736)IBA 01/2022 - 01/2021
2	palbociclibIBA 01/2022 - 01/2019
2	dabrafenibIBA 01/2021 - 03/2017
2	trametinibIBA 01/2021 - 03/2017
2	ezrinIBA 11/2020 - 01/2019
2	Vorinostat FDA Link 01/2020 - 01/2019
2	Temozolomide (Temodar)FDA LinkGeneric 01/2020 - 04/2016
2	LigandsIBA 12/2019 - 12/2013
2	EnzymesIBA 01/2019 - 01/2018
2	Sphingosine-1-Phosphate ReceptorsIBA 01/2019 - 01/2015
2	Carboplatin (JM8)FDA LinkGeneric 01/2019 - 01/2015
2	Ornithine Decarboxylase (Decarboxylase, Ornithine)IBA 01/2018 - 09/2017
2	Interleukin-8 (Interleukin 8)IBA 01/2018 - 01/2018
2	olaparibIBA 01/2018 - 05/2013
2	CytokinesIBA 10/2017 - 01/2014
2	Folic Acid (Vitamin M)FDA LinkGeneric 04/2016 - 01/2015
2	FumaratesIBA 04/2016 - 01/2014
2	Apoptosis Inducing FactorIBA 04/2016 - 01/2016
2	Reactive Oxygen Species (Oxygen Radicals)IBA 04/2016 - 12/2012
2	Janus KinasesIBA 04/2016 - 01/2016
2	ruxolitinibIBA 04/2016 - 01/2016
2	Anti-Bacterial Agents (Antibiotics)IBA 10/2015 - 07/2015
2	DNA (Deoxyribonucleic Acid)IBA 10/2015 - 07/2015
1	PhytochemicalsIBA 02/2022
1	Estrogen ReceptorsIBA 01/2022
1	Adenosine Triphosphatases (ATPase)IBA 12/2021
1	Amyloid beta-PeptidesIBA 12/2021
1	A-Form DNA (A-DNA)IBA 11/2020
1	lenvatinibIBA 01/2020
1	Mitochondrial Proteins (Mitochondrial Protein)IBA 01/2020

Therapy/Procedure

14	Therapeutics 01/2021 - 10/2013
7	Drug Therapy (Chemotherapy) 01/2020 - 10/2013
6	Immunotherapy 01/2020 - 09/2017
2	Precision Medicine 11/2019 - 01/2019
1	Neoadjuvant Therapy 10/2020